The impact of living alone on epigenomic and transcriptomic changes in pancreatic islets derived from male KK/Ta mice, a spontaneously diabetic strain.

Nammo, Takao; Funahashi, Nobuaki; Udagawa, Haruhide; Kozawa, Junji; Nakano, Kenta; Shimizu, Yukiko; Okamura, Tadashi; Kawaguchi, Miho; Uebanso, Takashi; Nishimura, Wataru; Hiramoto, Masaki; Shimomura, Iichiro; Yasuda, Kazuki

doi:10.6084/m9.figshare.21995645.v1

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genome.KK-HiJ.fa (2.58 GB)

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KK-HiJ.genes_annotation.gtf (89.06 MB)

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liftover_KKHiJToC57BL6J.chn (12.36 MB)

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The impact of living alone on epigenomic and transcriptomic changes in pancreatic islets derived from male KK/Ta mice, a spontaneously diabetic strain.

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posted on 2024-06-07, 01:30 authored by Takao NammoTakao Nammo, Nobuaki Funahashi, Haruhide Udagawa, Junji Kozawa, Kenta Nakano, Yukiko Shimizu, Tadashi Okamura, Miho Kawaguchi, Takashi Uebanso, Wataru Nishimura, Masaki Hiramoto, Iichiro Shimomura, Kazuki Yasuda

We investigated how the lack of social relationships accelerate the onset and development of diabetes through epigenomic regulation of gene expression in pancreatic islets derived from male KK mice, which has been known to be a polygenic model of mild obesity and type 2 diabetes.

The impact of living alone on epigenomic and transcriptomic changes in pancreatic islets derived from male KK/Ta mice, a spontaneously diabetic strain.

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