a comprehensive database of exosome molecular biomarkers and disease-gene associations

Exosomes play a crucial role in intercellular communication and can be used as biomarkers for diagnostic and therapeutic clinical applications. However, systematic studies in cancer-associated exosomal remain a big challenge. Here, we developed ExMdb, a comprehensive database of exosome molecular biomarkers and disease-gene associations curated from published literature and high-throughput datasets. ExMdb contains 4,586 experimentally supported gene-disease associations and 13,768 diagnostic and therapeutic biomarkers identified from experimental validation. By using ExMdb, users can quickly query detailed information onexosome features and sub-cellular locations for 28,314 genes manually curated from the literature and related data sources and 172 high-throughput datasets, including bulk and single-cell RNA sequencing (scRNA-seq) data. ExMdb also provides several user-friendly flexible tools to retrieve and analyse personalized immune infiltration, gene expression, cell cluster distribution, cell development trajectories, functional enrichment, and all possible related interactions of exosome features. Collectively, ExMdb will serve as an essential resource for investigating the regulation mechanism of complex diseases and improving the development of diagnostic and therapeutic biomarkers.The ExMdb is available athttp://www.bio-server.cn/ExMdb.