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<i>Ex vivo</i> adult <i>S</i>. <i>mansoni</i> worms after drug exposure.

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posted on 2021-06-24, 17:42 authored by Erik Koehne, Nina Zander, Miriam Rodi, Jana Held, Wolfgang Hoffmann, Rella Zoleko-Manego, Michael Ramharter, Ghyslain Mombo-Ngoma, Peter G. Kremsner, Andrea Kreidenweiss
<p>Worms were exposed to S3A) no drug (negative control), S3B) 1 μM praziquantel, S3C) 30 μM pyronaridine, and S3D) 30 μM methylene blue, respectively, for 7 days followed by an additional 7 days without drug (drug wash-out, but medium only).</p> <p>(ZIP)</p>

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    PLOS Neglected Tropical Diseases

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    Pyronaridine treatmentTrial registration ClinicalTrials.g...10 μ Mworm burdenmalaria parasitesprepatent stagespatient managementalternative treatment strategies1 controlSchistosoma Background Schistosomiasis30 μ Madult schistosomeshaematobium egg excretionantischistosomal compoundsantimalarial pyronaridineSchistosoma infectionsstage schistosomulaResults Amongst 16 drugsantiplasmodial compoundsmethyleneprepatent stagepilot trialantimalarial drugvivo activityschistosomiasis treatmentdrug resistance12 animalsConclusion Pyronaridineantimalarial drug combination pyron...4 childrenvivo adult wormsmice adult stagesschistosome infectionsadult worms

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