<b>Fixed-Dose Ivermectin for Mass Drug Administration: Is it time to leave the dose pole behind? Insights from an Individual Participant Data Meta-Analysis.</b>
<p dir="ltr">This study is an Individual Participant Data Meta-analysis (IPD MA) that provides a comprehensive assessment of fixed-dose ivermectin regimens, using anthropometric data from over 700,000 participants across 53 countries endemic for STH. </p><p dir="ltr">IPD were obtained from two main sources: (1) studies on STH interventions conducted in endemic regions and (2) datasets from data repositories, accessed in compliance with their specific protocols.</p><p dir="ltr">The datasets underwent a five-step process: selection, standardization, compilation, cleaning, and consistency assessment. First, only variables of interest were retained, excluding others from the original studies. Next, standardization ensured consistency across datasets: age was recorded in months (children) or years (adults), weight in kilograms (one decimal), and height in centimetres (one decimal). Each site was coded by country.</p><p dir="ltr">The resulting datasets organized in three different documents by age group (PSAC, SAC and WRA) and corresponding user-manuals are made available for reuse by other researchers in this data repository.</p>
Funding
This research is part of the STOP2030 project, supported by the Global Health EDCTP3 Joint Undertaking and its members, and has received funding from the European Union’s Horizon Europe research and innovation programme under grant agreement Nº 101103089. STOP2030 is also funded by the Federal Department of Economic Affairs, Education and Research (EAER) and the State Secretariat for Education, Research and Innovation (SERI) of the Swiss Confederation.
The study was conducted as part of a postdoctoral fellowship awarded to Adriana Echazu by Mundo Sano Foundation