The addition of 0.75 mg/kg matrine to the feed has the advantages of improving the production performance of piglets, increasing the positive rate of PCV2 vaccine antibody, and improving the production efficiency of pig farms. The mechanism of matrine improving production performance may be related to Gemmiger formicilisand thiamine. In addition, matrine has the advantages of abundant resources and low price in China, and it is urgent to be developed as a pig growth-promoting feed additive to contribute to the safe, efficient,and sustainable development of the pig industry in China and the world.