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Single-marker transmission disequilibrium tests in the detection sample (424 obesity trios), the confirmation sample (363 obesity trios) and in the joint sample (787 obesity trios).

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posted on 20.02.2013, 22:19 by André Scherag, Ivonne Jarick, Jessica Grothe, Heike Biebermann, Susann Scherag, Anna-Lena Volckmar, Carla Ivane Ganz Vogel, Brandon Greene, Johannes Hebebrand, Anke Hinney

base pair position on chromosome 18 according to (hg18);


obesity effect allele frequency;


confidence interval;


p-values were calculated using PLINKs′ adaptive permutation procedure with 106 permutations.

Displayed are the SNPs included in the three best haplotypes (Table 1) for the explored genomic region surrounding the melanocortin 4 receptor gene (MC4R, location: chromosome 18: 55,879,013–56,243,921 bps). The obesity-predisposing allele (obesity effect allele) within each sample is highlighted in bold.