Table_2.xls (9.5 kB)

Single-marker transmission disequilibrium tests in the detection sample (424 obesity trios), the confirmation sample (363 obesity trios) and in the joint sample (787 obesity trios).

dataset

posted on 2013-02-20, 22:19 authored by André Scherag, Ivonne Jarick, Jessica Grothe, Heike Biebermann, Susann Scherag, Anna-Lena Volckmar, Carla Ivane Ganz Vogel, Brandon Greene, Johannes Hebebrand, Anke Hinney

a

base pair position on chromosome 18 according to http://www.ncbi.nlm.nih.gov (hg18);

b

obesity effect allele frequency;

c

confidence interval;

d

p-values were calculated using PLINKs′ adaptive permutation procedure with 10⁶ permutations.

Displayed are the SNPs included in the three best haplotypes (Table 1) for the explored genomic region surrounding the melanocortin 4 receptor gene (MC4R, location: chromosome 18: 55,879,013–56,243,921 bps). The obesity-predisposing allele (obesity effect allele) within each sample is highlighted in bold.