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Signal detection for statin-associated muscular adverse events.

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posted on 20.02.2013, 10:36 by Toshiyuki Sakaeda, Kaori Kadoyama, Yasushi Okuno

N: the number of co-occurrences.

PRR: the proportional reporting ratio [19], ROR: the reporting odds ratio [20], IC: the information component [21], EBGM: the empirical Bayes geometric mean [22].

CI: the confidence interval; two-sided for ROR and IC, and one-sided for EBGM.

*: signal detected, see “Methods” for the criteria of detection.

Myalgia, rhabdomyolysis and increase of creatine phosphokinase (CPK) level were coded as PT10028411, PT10039020 and PT10005470, respectively.