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Pharmacokinetic parameter of oxycodone and its metabolites.

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posted on 2014-08-14, 10:24 authored by Yutaka Fujiwara, Masanori Toyoda, Naoko Chayahara, Naomi Kiyota, Takanobu Shimada, Yoshinori Imamura, Toru Mukohara, Hironobu Minami

Abbreviations: Cmax, peak plasma concentration; Tmax, time to peak plasma concentration; AUC0→8, area under the time-concentration curve from 0 to 8 hours; ratio, the ratio of the geometric mean value of CR oxycodone with aprepitant to those without aprepitant.

Geometric mean (% coefficient variance).

Values were corrected for dose, assuming that all patients received 20 mg of oxycodone.

*Paired t-test for difference between logarithmic geometric means (two-sided).

**Five patients were excluded due to below lower limit of quantitation.