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Pathway enrichment analysis of differentially expressed genes.

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posted on 08.10.2015 by Swanhild U. Meyer, Stefan Krebs, Christian Thirion, Helmut Blum, Sabine Krause, Michael W. Pfaffl

Signal transduction pathway associations, which were enriched after 4 h (“induction of differentiation”/immediate response), and 12 h (very early differentiation) of treatment, and 24 h (early differentiation) treatment, are depicted. The effects of differentiation without or with TNF-α or with IGF1 compared with TNF-α treatment are shown. Pathway enrichment was based on cocitation with a p value cutoff of <0.01. Genes within significantly enriched pathways are listed. In addition, it is indicated in which SOTA cluster a pathway is enriched. Pathways highlighted in bold are retrieved in enrichment analyses of genes identified by principal component analysis which are shown in Table 1.

Pathway enrichment analysis of differentially expressed genes.

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