PMM resistance selection in promastigotes: in vitro PMM susceptibility (IC50) of L. donovani parasites cultured as promastigotes under increasing PMM drug pressure.
To determine amastigote susceptibility of the induced promastigotes, stationary-phase stages were used to infect mouse primary macrophages and J774 macrophages.
P = parent non selected strain/R = selected resistant strain
nd = not done.*
BPK087/0 cl-11: susceptible to SbIII (IC50<15 µg/ml eq.) and resistant to SbV (IC50>77 µg/ml eq.)