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Number of potential bioactive peptides (per protein molecule) predicted to be released and AD1 value after gastric plus small intestinal digestion for gut endogenous proteins secreted in the mouth and stomach and selected dietary proteins based on an in silico digestion model.

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posted on 05.06.2014, 04:12 authored by Lakshmi A. Dave, Carlos A. Montoya, Shane M. Rutherfurd, Paul J. Moughan

AD value is the frequency of occurrence of bioactive peptides after digestion of the protein, calculated as where, aD is the number of identified bioactive peptides present after the simulated (in silico) digestion and N is the total number of amino acid residues within the protein.


2 ACE-inhibitor, 4 stimulating (glucose uptake-, -vasoactive substance release), 5 regulating (ion flow-, stomach mucosal membrane activity-), 6 antioxidative, 8 inhibitor (dipeptidyl peptidase IV inhibitor-, dipeptidyl-aminopeptidase IV inhibitor-, dipeptidyl carboxypeptidase-, CaMPDE-, neuropeptide-), 9 hypotensive, 10 activating ubiquitin mediated proteolysis.


The total number of peptides released is a summation of all the bioactive peptides predicted to be released after digestion of the intact proteins.


Some of the predicted bioactive peptides have more than one activity. Hence the total number of bioactive peptides released may be less than the summation of the number of bioactive peptides from the individual activity categories.