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Nested ordered-subset analysis in the subgroup with early-onset schizophrenia by CPT or WCST.

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posted on 20.02.2013, 15:24 by Yin-Ju Lien, Po-Chang Hsiao, Chih-Min Liu, Stephen V. Faraone, Ming T. Tsuang, Hai-Gwo Hwu, Wei J. Chen

Families were randomly permuted for 1000 times with respect to the covariate ranking and a chromosome-wide p value for each chromosome was yielded.


Significance level derived from simulations; a genome-wide empirical p-value <0.0015 [i.e., 0.05/33 covariates)] is denoted in boldface as reaching genome-wide significance.

*P<0.0001 for the mixed effect model comparing the families covariate values between the nested subset of families and the remaining ones.