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NF-κB is required for the formation of Eda induced supernumerary mammary placodes.

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posted on 2015-11-18, 12:49 authored by Maria Voutilainen, Päivi H. Lindfors, Ewelina Trela, Darielle Lönnblad, Vera Shirokova, Teresa Elo, Elisa Rysti, Ruth Schmidt-Ullrich, Pascal Schneider, Marja L. Mikkola

(A-C) Expression of Tbx3 (A), Wnt10b (B) and PTHrP (C) was detected in the mammary buds of the WT, K14-Eda, IκBαΔN and compound IκBαΔN; K14-Eda embryos at E13.5. Arrows highlight the supernumerary mammary placodes in K14-Eda embryos. Note that no localized expression was visible between the 3rd and the 4th mammary bud in the compound IκBαΔN; K14-Eda embryos. (D) Scanning electron microscopy images of the mammary forming region confirmed absence of accessory mammary primordia in compound mutants. (Scale bar: 500 μm.)