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Myc increases the severity of spontaneous DSB-mediated mutations.

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posted on 06.09.2013, 01:45 by Christina Greer, Moonsook Lee, Maaike Westerhof, Brandon Milholland, Rebecca Spokony, Jan Vijg, Julie Secombe

Control larvae are labeled as “+” and are the genotype hs-FLP/+ (or Y); lacZ #2/+; actin>CD2>Gal4, UAS-GFP/+ and Myc overexpressing larvae are labeled “Myc” and are the genotype hs-FLP/+ (or Y); lacZ #2/+; actin>CD2>Gal4, UAS-GFP/UAS-Myc. N indicates the number of breakpoint events counted. “Indels” are insertion and deletion events within the lacZ gene and translocations involve sequence within the lacZ reporter gene from another chromosome. Small indels are defined as less then 10 kb and large indels are 10 kb or greater.

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