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Mutational study of the EGFR feedback monomerization at the PLCγ binding sites.

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posted on 14.10.2015 by Malgorzata Kluba, Yves Engelborghs, Johan Hofkens, Hideaki Mizuno

a F stands for the phosphodeficient mutation (phenylalanine substitution).

b The strength of negative feedback scaled from as strong as for the EGFRwt (+ +) to none (—).

c, d Minimum (Dmin) and maximum (Dmax) level of the diffusion coefficient.

e The diffusion coefficient averaged over the whole measurement time after EGF addition (Davg).

f Not determinable.

Mutational study of the EGFR feedback monomerization at the PLCγ binding sites.

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