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Mediation analysis on effect of INR-variability on the increased risks of major adverse cardiovascular events and major bleeding complications in patients with chronic kidney disease in a nested case-control study.

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posted on 09.05.2014, 03:39 by Judith Kooiman, Nienke van Rein, Bas Spaans, Koen A. J. van Beers, Jonna R. Bank, Wilke R. van de Peppel, Antonio Iglesias del Sol, Suzanne C. Cannegieter, Ton J. Rabelink, Gregory Y. H. Lip, Frederikus A. Klok, Menno V. Huisman

Model 1 includes age, gender, hypertension, the use of platelet-inhibitors, diabetes mellitus and congestive heart failure.

Model 2 includes model 1 + INR VAR entire treatment period, Model 3 includes model 1 + INR variability over six months prior to event.

Model 4 includes model 1 + INR variability over three months prior to event.

Abbreviations: CKD  =  chronic kidney disease, MACE  =  major adverse cardiovascular event, OR  =  odds ratio, TIA  =  transient ischemic attack.

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