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Median survival of C57BL/6J, A/J, and Chromosome substituted strain (CSS) mice after intraperitoneal injection with S. aureus (107 CFU/g).

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posted on 02.09.2010, 00:52 by Sun-Hee Ahn, Hitesh Deshmukh, Nicole Johnson, Lindsay G. Cowell, Thomas H. Rude, William K. Scott, Charlotte L. Nelson, Aimee K. Zaas, Douglas A. Marchuk, Sehoon Keum, Supaporn Lamlertthon, Batu K. Sharma-Kuinkel, Gregory D. Sempowski, Vance G. Fowler Jr

CSS mice contain a single A/J chromosome inserted in C57BL/6J background. Thus, CSS 1 contains A/J chromosome 1 inserted in C57BL/6J background, etc. CSS strains 8, 11 and 18 were significantly more susceptible to S. aureus infection than C57BL/6J (P = 0.0027, 0.0023, and 0.0023, respectively).

*Compared to survival for C57BL/6J. Comparison of survival curves was performed by use of log rank test. Values of P<0.05 were considered significant.

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