Median survival of C57BL/6J, A/J, and Chromosome substituted strain (CSS) mice after intraperitoneal injection with S. aureus (107 CFU/g).
CSS mice contain a single A/J chromosome inserted in C57BL/6J background. Thus, CSS 1 contains A/J chromosome 1 inserted in C57BL/6J background, etc. CSS strains 8, 11 and 18 were significantly more susceptible to S. aureus infection than C57BL/6J (P = 0.0027, 0.0023, and 0.0023, respectively).
*Compared to survival for C57BL/6J. Comparison of survival curves was performed by use of log rank test. Values of P<0.05 were considered significant.