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Locus description and somatic mutational properties of three highly mutable 3′UTR microsatellites.

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posted on 2009-11-02, 02:15 authored by Bogdan C. Paun, Yulan Cheng, Barbara A. Leggett, Joanne Young, Stephen J. Meltzer, Yuriko Mori

Locus information and overall mutation prevalence describes the genetic attributes and mutation status in MSI-H colon tumors for microsatellites located within the 3′UTRs of RB1CC1, NUAK1, and RTF1.


PhastCons score: Mean and standard deviation of basewise microsatellite sequence conservation score among 31 placental mammals. The value closer to 1 indicates a high conservation level, and a large standard deviation indicates a change in conservation pattern within the microsatellite.


Flanking miR binding sites: Putative miR binding sites predicted by TargetScan and miRanda scripts within 200 bases of the 3′ or 5′ flanking regions of the corresponding microsatellite.


Flanking ARE motifs: presence of AU-rich elements within the 3′UTR, according to the Integrated ARED database.


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