List of PCL compounds confirmed in dose-response assays.
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posted on 2014-10-28, 18:54 authored by Stella M. Bernardo, Christopher P. Allen, Anna Waller, Susan M. Young, Tudor Oprea, Larry A. Sklar, Samuel A. Lee*The arrow indicates whether a compound elicited an increase (inducer) or decrease (inhibitor) in expression levels, as measured by fold-response of the GFP-tagged protein.
EC50 (in µM) values are reported for each respective compound confirmed as a hit, as determined in subsequent dose-response assays.
“n.d.” signifies that the hit was not confirmed in dose-response assays and therefore, no EC50 values have been determined.
List of PCL compounds confirmed in dose-response assays.
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microtiter plate formattarget proteinsantifungal drugsgene encoding candidate drug targetsantifungal agentsrepurposed agentscompoundSecondary assaysfluorescence intensityprobe candidate drug targetsflow cytometry sampling systeminducervirulence proteinsalbicans strainsIdentify Novel Compoundsvirulence characteristicseffortinhibitorpathogen Candida albicansHyperCyt systemantifungal drug resistanceprotein levelsmodulationmoleculemultiplexed screening methodPrestwick Chemical LibraryGFP levels
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