Leave-one-out cross-validation results of all methods on the NCBI PPI network.
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Results of each tested prioritization method on the NCBI PPI network. Mean and standard deviation of four evaluation measures (AUC, MAP, and percentage of left-out genes ranked in tops 10 and 20), obtained for 10 complete leave-one-out cross-validations on the 29 disease sets using 10 distinct previously generated candidate sets. ‘SRec’: percentage of left-out genes (from the total number of seeds in the original seed sets: 620) effectively ranked, that is, yielding a ranking score larger than zero. ‘DRec’: percentage of recovered diseases among the 29 diseases with seeds (a disease is recovered if at least one of its left-out genes obtained a ranking score larger than zero). ‘SEval’: percentage of left-out genes (from the total number of seeds originally in the seed sets: 620) in the network. All evaluation measures, AUC, MAP, TOP 10 and TOP 20, were computed taking into account only the left-out genes present in each network (SEval), rather than all the genes originally in the seed sets. Parameters: HDiffusion (, ), PRank (, ).