Latencies to pilocarpine-induced seizures and status epilepticus (SE) as assessed by behavioral observation.
Behavioral seizures were evaluated according to a modified Racine's scale . Latencies (min) to non-convulsive (stages 1–3) or convulsive (stages 4–5) seizures of Racine's scale were not different among the various treatment groups (P>0.05; one-way ANOVA). The delay to SE onset after the first Racine's stage 4–5 seizure was also similar in the different groups of pilocarpine-treated rats. Note also that all rats, independently of drug treatment, experienced non-convulsive followed by convulsive seizures, and then SE.*
t0 = pilocarpine injection.#
t0 = first behavioral stage 4–5 seizure.