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Latencies to pilocarpine-induced seizures and status epilepticus (SE) as assessed by behavioral observation.

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posted on 2013-08-28, 02:16 authored by Chiara Lucchi, Giulia Curia, Jonathan Vinet, Fabio Gualtieri, Elena Bresciani, Vittorio Locatelli, Antonio Torsello, Giuseppe Biagini

Behavioral seizures were evaluated according to a modified Racine's scale [31]. Latencies (min) to non-convulsive (stages 1–3) or convulsive (stages 4–5) seizures of Racine's scale were not different among the various treatment groups (P>0.05; one-way ANOVA). The delay to SE onset after the first Racine's stage 4–5 seizure was also similar in the different groups of pilocarpine-treated rats. Note also that all rats, independently of drug treatment, experienced non-convulsive followed by convulsive seizures, and then SE.


t0 = pilocarpine injection.


t0 = first behavioral stage 4–5 seizure.