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Experimental TSEs transmission results to TgOvPrP4 ovine transgenic mice.

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posted on 21.02.2013, 04:19 by Jean-Noël Arsac, Dominique Bétemps, Eric Morignat, Cécile Féraudet, Anna Bencsik, Denise Aubert, Jacques Grassi, Thierry Baron

Animals were inoculated intracerebrally with 2 mg brain tissue.


Genotype of sheep or goat (amino acids 136, 141, 154, and 171).

Experimental inoculums were divided into 2 different groups. Group 3: small ruminants intracerebrally inoculated with various TSEs. Group 4: experimental strains initially derived from wild-type mice. Detection of PrPres/PrPsc was performed by Western blot or IHC analyses.