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Effects of chalcones and flavones on BMP signaling.

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posted on 19.03.2013, 02:17 by Karen Vrijens, Wenwei Lin, Jimmy Cui, Dana Farmer, Jonathan Low, Elodie Pronier, Fu-Yue Zeng, Anang A. Shelat, Kiplin Guy, Michael R. Taylor, Taosheng Chen, Martine F. Roussel

(SJ) St Jude Children's Research Hospital; (DR) dose response; WB: Immunoblotting detecting activation of BMP signaling, phosphorylation of Smad1, 5, and expression of Id1 and Id2 in a dose-dependent manner; (+): significantly different from DMSO; (­): no significant difference from DMSO control (as calculated with student's t-test). Fold induction was calculated using Image J software. Phenotype of wild type zebrafish embryos was analyzed after treatment with compounds from 2 hpf until 30 hpf.

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