Distances between the Zn atom and its coordinating atomsa.
Mean values and standard deviations are in Å.b
Distance between Zn and the ligand backbone carbonyl oxygen of the scissile bond.c
Mean values and standard deviations obtained by averaging over 9 PDB structures of aminopeptidase N: P. falciparum (3EBH, 3EBI, 3EBG; ), E. coli (2ZXG; ), E. coli (2HPT, 2HPO; ), E. coli (2DQM, 2DQ6; ), N. meningitidis (2GTQ; ). The protein atom-Zn distances are the means of 9 measurements, while the water molecule distance is the mean distance measured from 4 unliganded structures.d
From PfA-M1 simulations, distances sampled every 50 ps over the 75 ns simulations.