Table_1.xls (9.5 kB)

Comparative effects of selective enzyme inhibition on 125I-Ang-(1–12) metabolism in medium of cultured neonatal wky and shr cardiac myocytes.

Download (0 kB)
dataset
posted on 20.02.2013 by Sarfaraz Ahmad, Jasmina Varagic, Brian M. Westwood, Mark C. Chappell, Carlos M. Ferrario

Values are expressed as % (Mean ± SE) of Ang-(1–12) unmetabolized* and Ang peptides (%) generated from 125I-Ang-(1–12) in the cultured medium incubated for 60 min at 37°C to WKY or SHR myocytes with or without the presence of RAS inhibitors. No inhibitors group: Only aminopeptidases inhibitors (amastatin & bestatin) and carboxypeptidases inhibitor (benzyl succinate); All inhibitors group: Aminopeptidases and carboxypeptidases inhibitors + RAS inhibitors (lisinopril, SCH39370, MLN-4760 & chymostatin); Minus RAS inhibitor groups: One of the RAS inhibitor (lisinopril/SCH39370/MLN-4760/chymostatin) omitted at a time from all inhibitors group. All values are expressed as (%) and are the average of three or more independent assays.

*Percent of 125IAng-(1–12) parent control remained un-metabolized in the medium exposed to WKY or SHR myocytes for 60 min at 37°C.

a

Significantly different (P<0.05) in No RAS inhibitors group vs. corresponding WKY or SHR group of +All RAS inhibitors.

b

Significantly different (P<0.05) vs. corresponding group of +All RAS inhibitors.

c

Significantly different (P<0.05) vs. corresponding WKY.

History

Licence

Exports

Logo branding

Licence

Exports