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Comparative effects of selective enzyme inhibition on 125I-Ang-(1–12) metabolism in medium of cultured neonatal wky and shr cardiac myocytes.

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posted on 20.02.2013 by Sarfaraz Ahmad, Jasmina Varagic, Brian M. Westwood, Mark C. Chappell, Carlos M. Ferrario

Values are expressed as % (Mean ± SE) of Ang-(1–12) unmetabolized* and Ang peptides (%) generated from 125I-Ang-(1–12) in the cultured medium incubated for 60 min at 37°C to WKY or SHR myocytes with or without the presence of RAS inhibitors. No inhibitors group: Only aminopeptidases inhibitors (amastatin & bestatin) and carboxypeptidases inhibitor (benzyl succinate); All inhibitors group: Aminopeptidases and carboxypeptidases inhibitors + RAS inhibitors (lisinopril, SCH39370, MLN-4760 & chymostatin); Minus RAS inhibitor groups: One of the RAS inhibitor (lisinopril/SCH39370/MLN-4760/chymostatin) omitted at a time from all inhibitors group. All values are expressed as (%) and are the average of three or more independent assays.

*Percent of 125IAng-(1–12) parent control remained un-metabolized in the medium exposed to WKY or SHR myocytes for 60 min at 37°C.


Significantly different (P<0.05) in No RAS inhibitors group vs. corresponding WKY or SHR group of +All RAS inhibitors.


Significantly different (P<0.05) vs. corresponding group of +All RAS inhibitors.


Significantly different (P<0.05) vs. corresponding WKY.




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