Changes in poisoning deaths involving co-proxamol, other analgesics, and all drugs, in England and Wales, 1998–2010, associated with the Committee on Safety of Medicines (CSM) announcement in January 2005.

a

Using interrupted time-series segmented regression analysis where the intervention point is taken as the end of 2004 (the CSM announcement on the withdrawal of co-proxamol, January 2005).

b

Estimated for the midpoint quarter of 2005–2010. See Text S1 for method, equation (2) or (3).

c

Absolute difference of estimated number with CSM announcement and estimated number without CSM announcement, taken at the mid-point of the post-intervention period, see Text S1 equation (4).

d

95% CIs taken from Stata results or calculated according to Zhang et al. [38].

e

Other analgesics include: co-codamol, codeine, co-dydramol, dihydrocodeine, NSAIDS, paracetamol, and tramadol.