Table S1 - Brain’s Reward Circuits Mediate Itch Relief. A Functional MRI Study of Active Scratching
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Regions of interest involved in the brain processing of itch significantly impacted by scratching. Brain areas correlated with itch relief and scratching pleasurability are shown. The highest Z scores > 2.3 are presented for most significantly correlated clusters. *Deactivated in a higher-level contrast analysis in comparison to itch condition. # Results of regression analyses performed for active scratching an itch are displayed. BA = Brodmann area; ACC = anterior cingulate cortex; PCC = posterior cingulate cortex; VTA = ventral tegmental area; PAG = periaqueductal gray; VPL= ventral posterolateral nucleus; VPM = ventral posteromedial nucleus; AN = anterior nucleus; LON = lateral posterior nucleus; LDN = lateral dorsal nucleus; MD = mediodorsal nucleus.