Blocking of FPR1 abrogates neutrophil migration to fMet-Leu-Phe and gliadin.
datasetposted on 2015-09-17, 03:40 authored by Karen M. Lammers, Marcello Chieppa, Lunhua Liu, Song Liu, Tatsushi Omatsu, Mirkka Janka-Junttila, Vincenzo Casolaro, Hans-Christian Reinecker, Carole A. Parent, Alessio Fasano
Pretreatment of neutrophils with cyclosporine H, a specific inhibitor of FPR1, completely abrogated the neutrophil migration induced by PT-gliadin and fMet-Leu-Phe. As expected, LTB4 induced neutrophil chemotaxis was not affected by cyclosporine H.
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gliadin exposure.MethodsUtilizing immunofluorescence microscopyneutrophil recruitmentFPR 1CD 11b cellsvivo intravital microscopygliadin peptide motifsFormyl Peptide Receptor57BLFPR 1 BackgroundGliadinzoneutrophil chemoattractant propertiesGliadin Induces Neutrophil Migrationchemotaxis assaysluminal gliadin exposureneutrophil chemoattractantgfp