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Association of lipid genotype risk scores with LOAD per one unit increase in lipid levels excluding population controls from the MRC-WTCCC2 group.

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posted on 16.09.2014, 03:05 by Petroula Proitsi, Michelle K. Lupton, Latha Velayudhan, Stephen Newhouse, Isabella Fogh, Magda Tsolaki, Makrina Daniilidou, Megan Pritchard, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Vellas, Julie Williams, Robert Stewart, Pak Sham, Simon Lovestone, John F. Powell

Scores were calculated using all independent SNPs associated with each trait (full) and SNPs associated exclusively with each trait (trait specific) for all datasets and pooled together using inverse-variance fixed effects meta-analysis. Full allele scores were calculated using both raw genotype data and summary data. Trait specific allele scores were calculated using summary data only. Since there was some evidence for between study heterogeneity, random effects models were also tested but did not affect the meta-analysis results.

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Association of lipid genotype risk scores with LOAD per one unit increase in lipid levels excluding population controls from the MRC-WTCCC2 group.

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