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Association between NT-proBNP and the risk of incident heart failure, overall and stratified by status of obesity.

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posted on 25.11.2014 by Janine Wirth, Brian Buijsse, Romina di Giuseppe, Andreas Fritsche, Hans W. Hense, Sabine Westphal, Berend Isermann, Heiner Boeing, Cornelia Weikert

a Person years are calculated from the sub-cohort (n = 1,163) only.

b adjusted for sex, stratified for baseline age.

c Model 1 further adjusted for educational degree, physical activity, smoking status, alcohol consumption, waist circumference, and prevalent diseases (diabetes, coronary heart disease, hypertension).

d Model 2 further adjusted for biomarkers (hsCRP, creatinine, total cholesterol and HDL cholesterol).

*p for trend across tertiles was calculated by using tertiles of N-terminal pro brain natriuretic peptide (NT-proBNP) as a categorical variable in the respective Cox proportional hazards regression models.

$the p value for nonlinearity was calculated by Wald chisquare test following restricted cubic spline Cox regression analysis.

#in the non-stratified models, body mass index (BMI) was also included in the adjustment set.

Association between NT-proBNP and the risk of incident heart failure, overall and stratified by status of obesity.

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