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Additional figures for 'Ancestry-inclusive dog genomics challenges popular breed stereotypes'
We performed mixed linear model-based associations with a leave-one-chromosome-out approach (MLMA-LOCO) using GCTA. Included were categorical covariates for sex and data type (genotyping or low-pass sequencing), as well as quantitative covariates for height and age for non-morphological traits. SNPs in linkage disequilibrium (r2 > 0.5) and within range (250 kb) of significantly associated index SNPs (p = 5e-8) and loosely associated index SNPs (p = 1e-6) were clumped. For each study, we plotted the -log10(p-value) across the genome, the distribution of phenotypes in the cohort, and a Q-Q plot.
Funding
Transforming family dogs into a powerful and accessible model for human cancer
National Cancer Institute
Find out more...The 200 mammals project: sequencing genomes by a novel cost-effective method, yielding a high resolution annotation of the human genome
National Human Genome Research Institute
Find out more...The Dog Aging Project: Genetic and Environmental Determinants of Healthy Aging in Companion Dogs
National Institute on Aging
Find out more...Behavioral Genetics and Neuropsychiatric Disorders in a Natural Model System
National Institute of Mental Health
Find out more...A comprehensive canine genetics resource including gene and variation annotation
Office of the Director
Find out more...Advancing precision medicine through development of the canine comparative cancer model
National Cancer Institute
Find out more...Collaborative Research URoL: Epigenetics2: Epigenetic pathways to regulate homeostatic resilience: Model-based discovery of rules across diverse mammals
Directorate for Biological Sciences
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