What is in Our Kit? An Analysis of Building Blocks Used in Medicinal Chemistry Parallel Libraries
datasetposted on 2021-11-22, 20:01 authored by Ying Wang, Isabella Haight, Rishi Gupta, Anil Vasudevan
Building blocks are the molecular foundations for drug molecule design. The building block is one of the determining factors of final compound qualities in any given medicinal chemistry campaign. Herein, we describe our analysis of the building blocks used in parallel library synthesis at AbbVie. The results gave insights into the synthetic tractability and accessibilities of building blocks used in medicinal chemistry. Furthermore, our analysis showed that opportunities still exist for the identification and future incorporation of underrepresented building blocks, even for commonly used reactions, to obtain intellectual and competitive advantages in drug discovery.
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results gave insightsparallel library synthesisopportunities still existfinal compound qualitiescommonly used reactionsunderrepresented building blocksbuilding blocks useddrug molecule designbuilding blockdrug discoverysynthetic tractabilityobtain intellectualmolecular foundationsmedicinal chemistryfuture incorporationdetermining factorscompetitive advantages