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Vitepyrroloids A–D, 2‑Cyanopyrrole-Containing Labdane Diterpenoid Alkaloids from the Leaves of Vitex trifolia

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posted on 28.04.2017, 15:41 by Pan Luo, Wenjuan Xia, Susan L. Morris-Natschke, Kuo-Hsiung Lee, Yu Zhao, Qiong Gu, Jun Xu
Vitepyrroloids A–D (14), four new 2-cyano-substituted pyrrole-ring-containing labdane diterpenoids, were isolated from the leaves of Vitex trifolia. Their structures were elucidated based on spectroscopic data analysis. The absolute configuration of compound 1 was determined by X-ray diffraction. Compounds 14 are unprecedented labdane diterpenoids featuring a 2-cyano-substituted pyrrole ring. Compound 1 showed cytotoxic activity against a human nasopharyngeal carcinoma cell line (CNE1) with an IC50 value of 8.7 μM.