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Vetiverianines A, B, and C: Sesquiterpenoids from Vetiveria zizanioides Roots

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posted on 2016-09-06, 19:14 authored by Yukiko Matsuo, Saori Maeda, Chika Ohba, Haruhiko Fukaya, Yoshihiro Mimaki
Three new sesquiterpenoidsvetiverianines A (1), B (2), and C (3)and a known eudesmane sesquiterpenoid (4) were isolated from the roots of Vetiveria zizanioides. Vetiverianine A (1) has a unique carbon framework comprising a rigid tricyclic ring system. Vetiverianines B (2) and C (3) are new eremophilane sesquiterpenoids. The structures of sesquiterpenoids 13, including the absolute configurations, were determined by NMR spectroscopic, X-ray crystallography, and vibrational circular dichroism data analysis. Vetiverianine C (3) exhibited weak cytotoxic activity against HL-60 cells.