The Middle Cumberland Region is a unique area of Mississippian period (ca. 1000-1500 CE) culture focused along the Cumberland River watershed of central Tennessee. This ArcGIS shapefile presents a polygon of the Middle Cumberland Region, based on archival research of both published and unpublished data on file at the Tennessee Division of Archaeology (Nashville, TN). The boundary is visualized in ArcMap 10.8.1 primarily using 10-digit Hydrologic Unit (HU-10) USGS Watershed Boundary data.