The First Total Synthesis of Nakadomarin A
datasetposted on 2003-05-29, 00:00 authored by Toshiaki Nagata, Masako Nakagawa, Atsushi Nishida
(−)-Nakadomarin A is a member of manzamine alkaloid isolated from a marine sponge and have a unique hexacyclic structure. The first total synthesis of (+)-nakadomarin A, an enantiomer of natural product, has been accomplished from stereochemically defined 4-oxopiperidin-3-carboxylic acid derivative. The synthesis established the structure of nakadomarin A including absolute configuration.