Table_2_High Glycemic Diet Is Related to Brain Amyloid Accumulation Over One Year in Preclinical Alzheimer's Disease.PDF
Objective: To test the hypothesis that high glycemic diet is related to 1-year change in brain amyloid based on our prior cross-sectional evidence that high glycemic diet is associated with brain amyloid.
Methods: This longitudinal, observational study assessed the relationship between reported habitual consumption of a high glycemic diet (HGDiet) pattern and 1-year brain amyloid change measured by Florbetapir F18 PET scans in 102 cognitively normal older adults with elevated or sub-threshold amyloid status that participated in a 1-year randomized, controlled exercise trial at the University of Kansas Medical Center in Kansas City.
Results: Among all participants (n = 102), higher daily intake of the HGDiet pattern (β = 0.06, p = 0.04), sugar (β = 0.07, p = 0.01), and total carbohydrate (β = 0.06, p = 0.04) were related to more precuneal amyloid accumulation. These relationships in the precuneus were accentuated in participants with elevated amyloid at enrollment (n = 70) where higher intake of the HGDiet pattern, sugar, and carbohydrate were related to more precuneal amyloid accumulation (β = 0.11, p = 0.01 for all measures). In individuals with elevated amyloid, higher intake of the HGDiet pattern was also related to more amyloid accumulation in the lateral temporal lobe (β = 0.09, p < 0.05) and posterior cingulate gyrus (β = 0.09, p < 0.05) and higher sugar and carbohydrate intake were also related to more amyloid accumulation in the posterior cingulate gyrus (β = 0.10, p < 0.05 for both measures).
Conclusion: This longitudinal observational analysis suggests that a high glycemic diet relates to higher brain amyloid accumulation over 1 year in regions of the temporoparietal cortex in cognitively normal adults, particularly in those with elevated amyloid status. Further studies are required to assess whether there is causal link between a high glycemic diet and brain amyloid.
Clinical Trial Registration:ClinicalTrials.gov, Identifier (NCT02000583).
History
References
- https://doi.org//10.3233/JAD-2006-9S317
- https://doi.org//10.1126/science.1566067
- https://doi.org//10.1016/j.mehy.2003.12.045
- https://doi.org//10.1016/j.jalz.2011.03.003
- https://doi.org//10.1016/j.jalz.2016.02.002
- https://doi.org//10.1212/01.wnl.0000333247.51383.43
- https://doi.org//10.1073/pnas.2635903100
- https://doi.org//10.1016/S2213-8587(14)70148-2
- https://doi.org//10.1016/j.neurobiolaging.2013.09.033
- https://doi.org//10.1016/j.brainresbull.2016.08.009
- https://doi.org//10.3945/ajcn.117.162263
- https://doi.org//10.1016/j.bbadis.2014.04.012
- https://doi.org//10.1371/journal.pone.0244893
- https://doi.org//10.1212/WNL.43.11.2412-a
- https://doi.org//10.1037/t01539-000
- https://doi.org//10.1093/aje/154.12.1089
- https://doi.org//10.1038/ejcn.2008.62
- https://doi.org//10.18637/jss.v065.i08
- https://doi.org//10.1017/S1368980019001289
- https://doi.org//10.1097/RLU.0000000000001693
- https://doi.org//10.1016/j.jalz.2017.01.022
- https://doi.org//10.1006/nimg.2001.0978
- https://doi.org//10.1016/j.jand.2018.05.021
- https://doi.org//10.1212/WNL.0b013e3182840bbe
- https://doi.org//10.1111/bph.14585
- https://doi.org//10.1093/ajcn/87.3.627
- https://doi.org//10.3390/nu11061280
- https://doi.org//10.1016/j.neurobiolaging.2016.04.017
- https://doi.org//10.1016/j.trci.2018.09.007
- https://doi.org//10.1002/hbm.22753
- https://doi.org//10.1073/pnas.1721259115
- https://doi.org//10.1162/jocn_a_01426
- https://doi.org//10.1523/JNEUROSCI.4227-13.2014
- https://doi.org//10.1093/brain/aww108
- https://doi.org//10.1038/s41467-017-01150-x
- https://doi.org//10.1002/ana.24910
- https://doi.org//10.1073/pnas.1317918110
- https://doi.org//10.1001/jamaneurol.2015.3098
- https://doi.org//10.1186/2051-5960-2-30
- https://doi.org//10.1161/CIRCULATIONAHA.109.192627
- https://doi.org//10.2337/dc08-1239
- https://doi.org//10.1016/j.jalz.2017.01.024
- https://doi.org//10.1161/01.ATV.0000238352.25222.5e
- https://doi.org//10.1016/S2213-8587(19)30074-9
- https://doi.org//10.1016/j.trci.2017.11.002
- https://doi.org//10.3390/nu11081910
- https://doi.org//10.1016/j.neurobiolaging.2019.09.015
- https://doi.org//10.3390/ijms21030934
- https://doi.org//10.1186/1743-7075-2-28
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