Table_1_The Biogenesis, Biology, and Clinical Significance of Exosomal PD-L1 in Cancer.docx (87.12 kB)
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Table_1_The Biogenesis, Biology, and Clinical Significance of Exosomal PD-L1 in Cancer.docx

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posted on 07.04.2020, 04:45 by Yanyan Tang, Ping Zhang, Yumin Wang, Jinpeng Wang, Min Su, Ying Wang, Lianqing Zhou, Jumei Zhou, Wei Xiong, Zhaoyang Zeng, Yujuan Zhou, Shaolin Nie, Qianjin Liao

The exosome serves as a trafficking vehicle for transport of programmed death-ligand 1 (PD-L1) into receptor cells. In tumor microenvironment, distant tumor cells can remotely attack activated T cells by exosomal PD-L1. Here, we summerize the biogenesis and transport process of exosomal PD-L1. Then, we focus on the cancer biology of exosomal PD-L1 in immunosuppression and the mechanism by which it inhibits T cells. Finally, we highlight the prospects of exosomal PD-L1 as a tumor biomarker and its significance in immunotherapy. In addition, we discuss the new challenges faced in researching and utilizing exosomal PD-L1. This review may shed light on the exosomal PD-L1 from the bench to the clinic. Exosomes serve as trafficking vehicles for transport of programmed death-ligand 1 (PD-L1) into receptor cells. In tumor microenvironment, distant tumor cells can remotely attack activated T cells through exosomal PD-L1. Here, we have summarized the biogenesis and transport of exosomal PD-L1. Next, we focused on the cancer biology of exosomal PD-L1 in immunosuppression and the mechanism by which it inhibits T cells. Finally, we highlighted the prospects of exosomal PD-L1 as a tumor biomarker and its significance in immunotherapy. In addition, we have discussed the new challenges faced in studying and utilizing exosomal PD-L1. This review may shed light on the translation of exosomal PD-L1 from bench to clinic.

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