Table_1_Altered Lipid Profiles and Vaccine Induced-Humoral Responses in Children Living With HIV on Antiretroviral Therapy in Tanzania.docx
People living with HIV, even under therapy, have a high burden of age-related co-morbidities including an increased risk of dyslipidemia (which often predisposes to cardiovascular diseases) and immune-aging. In this study, lipid profiles and antibody responses to measles and pertussis toxin vaccines were compared between ART experienced HIV+ children (n=64) aged 5-10 years, and their age- and sex-matched HIV- controls (n=47). Prevalence of high-density lipoprotein cholesterol (HDL-c) and triglyceride-driven dyslipidemia was higher among treated HIV+ children than in controls (51.6% vs 27.7% respectively, p < 0.019). In a multivariate Poisson regression model adjusted for age, sex and BMI, the association between low HDL-c, hypertriglyceridemia and HIV remained significantly high (for HDL-c: ARR: 0.89, 95% CI: 0.82 – 0.96, p = 0.003; for triglycerides: ARR: 1.54, 95% CI: 1.31 – 1.81, p < 0.001). Among HIV+ children, the use of lopinavir/ritonavir, a protease-based antiretroviral therapy was also associated elevation of triglyceride levels (p = 0.032). Also, HIV+ children had a 2.8-fold reduction of anti-measles IgG titers and 17.1-fold reduction of anti-pertussis toxin IgG levels when compared to HIV- children. Our findings suggest that dyslipidemia and inadequate vaccine-induced antibody responses observed in this population of young African HIV+ children might increase their risk for premature onset of cardiovascular illnesses and acquisition of preventable diseases.
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References
- https://doi.org//10.1093/ije/dyp306
- https://doi.org//10.1016/j.exger.2006.12.003
- https://doi.org//10.2147/IDR.S203813
- https://doi.org//10.2147/HIV.S296170
- https://doi.org//10.1093/infdis/jiv123
- https://doi.org//10.1097/QAI.0b013e3181b9869f
- https://doi.org//10.1016/j.canlet.2014.02.002
- https://doi.org//10.5501/wjv.v4.i2.56
- https://doi.org//10.1161/CIRCULATIONAHA.110.016170
- https://doi.org//10.1136/bmj.a3172
- https://doi.org//10.1371/journal.pone.0190785
- https://doi.org//10.1097/QAD.0000000000002923
- https://doi.org//10.1097/MPG.0000000000002630
- https://doi.org//10.1371/journal.pone.0250328
- https://doi.org//10.1097/QAD.0000000000001093
- https://doi.org//10.1093/infdis/jiz118
- https://doi.org//10.1093/cid/cir627
- https://doi.org//10.1097/QAD.0000000000001478
- https://doi.org//10.1371/journal.pone.0247004
- https://doi.org//10.7448/IAS.20.1.21952
- https://doi.org//10.1177/1178633720948860
- https://doi.org//10.1016/j.pedn.2012.11.003
- https://doi.org//10.11604/pamj.2017.27.40.9840
- https://doi.org//10.1186/s12879-017-2626-z
- https://doi.org//10.1007/s12098-015-1859-3
- https://doi.org//10.1016/j.jacc.2009.05.055
- https://doi.org//10.1542/peds.111.6.e641
- https://doi.org//10.1097/QAI.0b013e3181b79d22
- https://doi.org//10.1016/j.eclinm.2018.06.002
- https://doi.org//10.1016/j.ijcard.2015.07.052
- https://doi.org//10.1177/2325957415614642
- https://doi.org//10.1186/s12929-018-0490-9
- https://doi.org//10.1097/QAI.0000000000000419
- https://doi.org//10.1097/QAD.0b013e328363bf7f
- https://doi.org//10.1073/pnas.0901702106
- https://doi.org//10.1002/eji.201546178
- https://doi.org//10.1007/s40261-014-0266-2
- https://doi.org//10.1371/journal.pone.0021261
- https://doi.org//10.1093/cid/civ440
- https://doi.org//10.1080/14760584.2019.1547195
- https://doi.org//10.1089/aid.2012.0086
- https://doi.org//10.3390/jcm8040430
- https://doi.org//10.1097/QAI.0b013e31826bfc32
- https://doi.org//10.1097/MD.0000000000024800
- https://doi.org//10.1097/00042560-199609000-00013
- https://doi.org//10.1186/s12889-020-09598-1
- https://doi.org//10.1097/QAD.0000000000001810
- https://doi.org//10.1007/s10238-015-0376-z
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