ja038565t_si_001.cif (14.06 kB)
Synthesis of Medium Ring Nitrogen Heterocycles via a Tandem Copper-Catalyzed C−N Bond Formation−Ring-Expansion Process
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posted on 2004-03-24, 00:00 authored by Artis Klapars, Sean Parris, Kevin W. Anderson, Stephen L. BuchwaldA simple method for the preparation of medium ring heterocycles (7-, 8-, 9-, and 10-membered)
has been developed. The process employs a Cu-catalyzed coupling of a β-lactam with an aryl bromide or
iodide followed by intramolecular attack of a pendant amino group. In some instances, the intermediate
β-lactam is observable but can be converted to the aza-heterocycle by catalysis. Acetic acid was found to
be superior to transition metal complexes as a catalyst for this ring-expansion process.