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Supporting Information for Preprint "Prebiotic Vitamin B3 Synthesis in Carbonaceous Planetesimals"

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posted on 2023-10-17, 17:21 authored by Klaus PaschekKlaus Paschek, Mijin Lee, Dmitry A. Semenov, Thomas K. Henning

Aqueous chemistry within carbonaceous planetesimals is promising for synthesizing prebiotic organic matter essential to all life. Meteorites derived from these planetesimals delivered these life building blocks to the early Earth, potentially facilitating the origins of life. Here, we studied the formation of vitamin B3 as it is an important precursor of the coenzyme NAD(P)(H), which is essential for the metabolism of all life as we know it. We propose a new reaction mechanism based on known experiments in the literature that explains the synthesis of vitamin B3. It combines the sugar precursors glyceraldehyde or dihydroxyacetone with the amino acids aspartic acid or asparagine in aqueous solution without oxygen or other oxidizing agents. We performed thermochemical equilibrium calculations to test the thermodynamic favorability. The predicted vitamin B3 abundances resulting from this new pathway were compared with measured values in asteroids and meteorites. We conclude that competition for reactants and decomposition by hydrolysis are necessary to explain the prebiotic content of meteorites. In sum, our model fits well into the complex network of chemical pathways active in this environment.

Funding

Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy EXC 2181/1 - 390900948 (the Heidelberg STRUCTURES Excellence Cluster)

International Max Planck Research School for Astronomy and Cosmic Physics at the University of Heidelberg (IMPRS-HD)

European Research Council under the Horizon 2020 Framework Program via the ERC Advanced Grant Origins 83 24 28

History