Neuromuscular electrical stimulation (NMES) can potentially be used to prevent venous thromboembolism, however, its impact on coagulation-related factors remains poorly understood. We investigate the acute effects on coagulation- and cardiovascular factors immediately after a 2-hour NMES-session. The NMES-session resulted in a slight increase in the coagulative state, mirroring that seen after a bout of regular exercise. The changes observed in cardiovascular factors, which are mostly not directly related to coagulation, suggests that NMES may subsequently modulate inflammatory responses, warranting further investigation.