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Summary of supplementary MR-PL results with no winner’s curse correction (WC-correction) applied for pairs of imaging-derived phenotypes (IDPs) and complex traits having a non-zero causal effect estimate.

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posted on 2023-12-27, 18:40 authored by Anyi Yang, Yucheng T. Yang, Xing-Ming Zhao
<p>Summary of supplementary MR-PL results with no winner’s curse correction (WC-correction) applied for pairs of imaging-derived phenotypes (IDPs) and complex traits having a non-zero causal effect estimate.</p>

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    DOI - Is supplement to An augmented Mendelian randomization approach provides causality of brain imaging features on complex traits in a single biobank-scale dataset

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    PLOS Genetics

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    winner &# 8217partial least squaresbrain imaging featuresbrain imaging datablood vascular functionprecise causal estimatescomprehensive simulations confirmedunderpin complex traitsmatched complex traits180 complex traitscorrelation among exposurescomplex traitsrelated traitssystematic simulationscausal effectswidely appliedsample settingssample settingperformed extensivelasso regressionextremely upscaledeffective approachcurse biasalternative approachesalso correcting

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