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Short and Efficient Asymmetric Synthesis of (−)-α-Conhydrine

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posted on 06.07.2007, 00:00 by Arnaud Voituriez, Franck Ferreira, Fabrice Chemla
The short and efficient synthesis of (−)-α-conhydrine was accomplished with 41% overall yield in seven steps and high diastereo- and enantioselectivity. The anti-stereochemistry of the two stereogenic centers has been confirmed by the single-crystal X-ray analysis of an intermediate.

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