pone.0276717.s001.xlsx (51.72 kB)

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posted on 2022-12-09, 18:31 authored by Szu-Yu Liu, Chia-Chang Huang, Ying-Ying Yang, Shiang-Fen Huang, Tzung-Yan Lee, Tzu-Hao Li, Ming-Chih Hou, Han-Chieh Lin

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sup >+study evaluates whether farnesoid x receptor improved cardiac inflammation cardiac infiltrated cd3 ameliorate cardiac inflammation decreased left ventricle lower inflammasome levels exacerbate cardiac dysfunction xlink "> suppression less apoptotic cells increased fractional shortening cardiac inflammasome levels treatment improves nash reversing cardiac regulatory related cardiac dysfunction oca mice spleen higher intracellular fxr decreased cardiac fibrosis oca treatment suppressed cardiac dysfunction xlink ">oca treatment improving inflammasome cardiac iinflammasome cardiac fxr oca mice intracellular fxr increased levels cellular levels cell dysfunction cardiac treg nash mice vivo vitro two weeks represented anti related effects potential strategy positively correlated nonalcoholic steatohepatitis nash group mediated nash inflammatory cytokines induced hypocontractility increased fs fs )]downregulated differentiation contraction marker condition medium

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