ic202049t_si_002.cif (81.69 kB)
Download file

Role of Entropy and Autosolvation in Dimerization and Complexation of C60 by Zn7 Metallocavitands

Download (81.69 kB)
posted on 2012-03-19, 00:00 authored by Peter D. Frischmann, S. Hessam M. Mehr, Brian O. Patrick, Francesco Lelj, Mark J. MacLachlan
The supramolecular chemistry of bowl-shaped heptazinc metallocavitands templated by Schiff base macrocycles has been investigated. Dimerization thermodynamics were probed by 1H NMR spectroscopy in benzene-d6, toluene-d8, and p-xylene-d10 and revealed the process to be entropy-driven and enthalpy-opposed in each solvent. Trends in the experimentally determined enthalpy and entropy values are related to the thermodynamics of solvent autosolvation, solvent molecules being released from the monomeric metallocavitand cavity into the bulk solvent upon dimerization. The relationship established between experimentally measured dimerization thermodynamics and autosolvation data successfully predicts the absence of dimerization in CH2Cl2 and CHCl3 and was used to estimate the number of solvent molecules interacting with the monomeric metallocavitand in solution. Host–guest interactions between heptazinc metallocavitands and fullerene C60 have also been investigated. Interestingly, metallocavitand-C60 interactions are only observed in solvents that facilitate entropy-driven dimerization suggesting entropy and solvent autosolvation may be important in explaining concave-convex interactions.