DATASET
3.Data Repository_Renal and cardiac effects of PDE9 inhibitor.xlsx (5.48 MB)
DATASET
3.2 kidney_pathway.sig_Renal and cardiac effects of PDE9 inhibitor.xlsx (40.99 kB)
DATASET
3.3 Heart_pathway.sig_Renal and cardiac effects of PDE9 inhibitor.xlsx (33.04 kB)
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Renal and cardiac effects of the PDE9 inhibitor BAY 73-6691 in 5/6 nephrectomized rats.
Version 2 2023-10-13, 09:43
Version 1 2023-10-13, 09:18
dataset
posted on 2023-10-13, 09:43 authored by XIN CHENXIN CHEN, Denis Delić, Yaochen Cao, Zeyu Zhang, Hongwei Wu, Ahmed A. Hasan, Mohamed M.S. Gaballa, Lianghong Yin, Bernhard K· Krämer, Thomas Klein, Linghong Shen, Ben He, Berthold HocherWe examined the effects of the PDE9 inhibitor BAY 73-6691 on the kidney and heart for the first time in a 5/6 nephrectomy animal model using BAY 73-6691 dosages known to be effective in other rat disease models. We did not observe any relevant effects of the PDE9 inhibitor BAY 73-6691 on renal function, renal histology, and renal disease-related pathways and gene expression in 5/6 nephrectomy rats. In addition, the effects of the PDE9 inhibitor BAY 73-6691 on the heart of 5/6 nephrectomy rats were mild. Except for cardiomyocyte size, BAY 73-6691 had no effect on other cardiac histological parameters, cardiac function, and disease-related genes and pathways.
