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Regulatory function at the chromosome 10q24 leprosy association.

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posted on 2022-09-19, 17:42 authored by James J. Gilchrist, Kathryn Auckland, Tom Parks, Alexander J. Mentzer, Lily Goldblatt, Vivek Naranbhai, Gavin Band, Kirk A. Rockett, Ousmane B. Toure, Salimata Konate, Sibiri Sissoko, Abdoulaye A. Djimdé, Mahamadou A. Thera, Ogobara K. Doumbo, Samba Sow, Sian Floyd, Jörg M. Pönnighaus, David K. Warndorff, Amelia C. Crampin, Paul E. M. Fine, Benjamin P. Fairfax, Adrian V. S. Hill

Evidence for colocalisation between regulatory determinants of gene expression at 25 genes in cis (within 250kb) to the leprosy association across primary immune cells, skin and peripheral nerve tissue.