jo6b00950_si_002.cif (12.66 kB)

Regioselective 2,2,2-Trifluoroethylation of Imidazopyridines by Visible Light Photoredox Catalysis

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posted on 2016-06-21, 22:29 authored by Mei Zhu, Xin Han, Weijun Fu, Zhiqiang Wang, Baoming Ji, Xin-Qi Hao, Mao-Ping Song, Chen Xu
A visible-light-induced C-3 selective trifluoroethylation of imidazoheterocycles using 1,1,1-trifluoro-2-iodoethane as trifluoroethyl radical sources was developed. The methodology enables the introduction of a trifluoroethyl group in a fast and efficient reaction under mild conditions with excellent regioselectivities and high functional group tolerance.