Kohl 2016 Physics Chemistry Molecular epigenetics.pdf (430.88 kB)
RNA-mediated physics, chemistry, and molecular epigenetics
Olfaction and the innate immune system link energy as information from
the epigenetic landscape to the physical landscape of supercoiled DNA.
The sun's biological energy is the source of the information that links
angstroms to ecosystems via physics, chemistry, and molecular
epigenetics.
RNA-mediated protein folding chemistry and amino acid substitutions link the anti-entropic quantized energy of sunlight from the virucidal effects of ultraviolet (UV) light to healthy longevity via biophysically-constrained energy-dependent hydrogen-atom transfer in DNA base pairs in solution and cell type differentiation.
Biomarkers link energy-dependent differences in base pairs and amino acid substitutions to biosignatures across the healthy life span. RNA-mediated amino acid substitutions also reveal the increasing complexity of interactions among cell types as pathology progresses. For comparison, successful reproduction links energy from supercoiled DNA to protection of all organized genomes from virus-driven energy theft and pathology.
This model links the sun's biological energy from top-down causation in microbes to the most recent model of bottom-up gene activation and cell type differentiation in vertebrates. Citations to extant literature provide examples of what is currently known about how ecological variation leads to biophysically constrained cell type differentiation in the context of nutritional epigenetics and Precision Medicine, which clearly link metabolic networks and genetic networks to pharmacogenomics.
RNA-mediated protein folding chemistry and amino acid substitutions link the anti-entropic quantized energy of sunlight from the virucidal effects of ultraviolet (UV) light to healthy longevity via biophysically-constrained energy-dependent hydrogen-atom transfer in DNA base pairs in solution and cell type differentiation.
Biomarkers link energy-dependent differences in base pairs and amino acid substitutions to biosignatures across the healthy life span. RNA-mediated amino acid substitutions also reveal the increasing complexity of interactions among cell types as pathology progresses. For comparison, successful reproduction links energy from supercoiled DNA to protection of all organized genomes from virus-driven energy theft and pathology.
This model links the sun's biological energy from top-down causation in microbes to the most recent model of bottom-up gene activation and cell type differentiation in vertebrates. Citations to extant literature provide examples of what is currently known about how ecological variation leads to biophysically constrained cell type differentiation in the context of nutritional epigenetics and Precision Medicine, which clearly link metabolic networks and genetic networks to pharmacogenomics.
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- Animal behaviour
- Animal cell and molecular biology
- Animal physiological ecology
- Animal physiology - biophysics
- Behavioural neuroscience
- Behavioural ecology
- Biological adaptation
- Human biophysics
- Biochemistry and cell biology not elsewhere classified
- Cell metabolism
- Cellular interactions (incl. adhesion, matrix, cell wall)
- Evolution of developmental systems
- Ecological physiology
- Epigenetics (incl. genome methylation and epigenomics)
- Genetics not elsewhere classified
- Infectious diseases
- Immunology not elsewhere classified
- Life histories
- Other biomedical and clinical sciences not elsewhere classified
- Microbial ecology
- Plant cell and molecular biology
- Neurosciences not elsewhere classified
- Pathology (excl. oral pathology)
- Oral medicine and pathology
- Proteomics and intermolecular interactions (excl. medical proteomics)
- Receptors and membrane biology
- Signal transduction
- Speciation and extinction
- Structural biology (incl. macromolecular modelling)
- Virology
- Zoology not elsewhere classified
Keywords
ecosystem carbon dynamicsEpigenetic Gene RegulationAmino acid sequence comparisonsVirus Adaptation Determines Virus FitnessRNA bacteriophagegene editing technologylongevity-selectedadaptation mechanismsCell type specific expressionisoform diversityAnimal BehaviourAnimal Cell and Molecular BiologyAnimal Physiological EcologyAnimal Physiology - BiophysicsBehavioral NeuroscienceBehavioural EcologyBiological AdaptationBiophysicsCell BiologyCell MetabolismCellular Interactions (incl. Adhesion, Matrix, Cell Wall)Developmental BiologyEcological PhysiologyEpigenetics (incl. Genome Methylation and Epigenomics)GeneticsInfectious DiseasesImmunologyLife HistoriesMedicineMicrobial EcologyMolecular BiologyNeurosciencePathologyProteomics and Intermolecular Interactions (excl. Medical Proteomics)Receptors and Membrane BiologySignal TransductionSpeciation and ExtinctionStructural Biology (incl. Macromolecular Modelling)VirologyZoology