Olfaction and the innate immune system link energy as information from
the epigenetic landscape to the physical landscape of supercoiled DNA.
The sun's biological energy is the source of the information that links
angstroms to ecosystems via physics, chemistry, and molecular
epigenetics. RNA-mediated protein folding chemistry and amino acid
substitutions link the anti-entropic quantized energy of sunlight from
the virucidal effects of ultraviolet (UV) light to healthy longevity via
biophysically-constrained energy-dependent hydrogen-atom transfer in
DNA base pairs in solution and cell type differentiation. Biomarkers
link energy-dependent differences in base pairs and amino acid
substitutions to biosignatures across the healthy life span.
RNA-mediated amino acid substitutions also reveal the increasing
complexity of interactions among cell types as pathology progresses. For
comparison, successful reproduction links energy from supercoiled DNA
to protection of all organized genomes from virus-driven energy theft
and pathology. This model links the sun's biological energy from
top-down causation in microbes to the most recent model of bottom-up
gene activation and cell type differentiation in vertebrates. Citations
to extant literature provide examples of what is currently known about
how ecological variation leads to biophysically constrained cell type
differentiation in the context of nutritional epigenetics and Precision
Medicine, which clearly link metabolic networks and genetic networks to
pharmacogenomics.